ASSOCIATION OF PLASMA LEPTIN AND OMENTIN-1 WITH ORAL VITAMIN D INTAKE IN PATIENTS WITH CORONARY ARTERY DISEASES

Authors

  • Shazia Nazar Department of Physiology, Dow University of Health Sciences Karachi
  • Syeda Hina Abbas Department of Pathology, Dow University of Health Sciences Karachi
  • Syeda Sana Abbas Department of Medicine, Abbasi Shaheed Hospital Karachi

Keywords:

Biomarkers, Cardiac disease, Leptin, Omentin-1, Vitamin D

Abstract

Objective: To evaluate the association of oral vitamin D intake on leptin & omentin-1 circulating levels in patients diagnosed with coronary artery disease.

Material & Methods: The study was conducted at the Cardiology unit of Civil Hospital Karachi. A total count of 200 diagnosed patients of coronary artery disease with insufficient vitamin D and were prescribed oral vitamin D by their doctors, were selected for the study. Patients were assigned to the daily dose of 2000IU vitamin D for 8 weeks. Anthropometric measurements and circulating vitamin D, omentin-1 & leptin levels were assessed at the beginning and post-treatment.


Results: A notable decrease in leptin (3776 ± 0.422 vs. 3187 ± 0.144, p<0.001), omentin-1 (245 ± 26.1 vs. 296.5 ± 28.11, p < 0.001), and high density lipoprotein levels (36.80 ± 13.46 vs. 45.2 ± 14.31, p < 0.001) were found after oral vitamin D intake.


Conclusion: Vitamin D supplements over an 8-week period substantially reduced serum levels of leptin, whereas they raised omentin-1 and high density lipoprotein levels in coronary artery disease patients.

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Published

2024-12-31

How to Cite

Nazar, S., Hina Abbas, S. ., & Sana Abbas, S. . (2024). ASSOCIATION OF PLASMA LEPTIN AND OMENTIN-1 WITH ORAL VITAMIN D INTAKE IN PATIENTS WITH CORONARY ARTERY DISEASES. Annals of Allied Health Sciences, 10(2), 34–38. Retrieved from https://aahs.kmu.edu.pk/index.php/aahs/article/view/265

Issue

Vol. 10 No. 2 (2024): Annals of Allied Health Sciences

Section

Articles

License

Copyright (c) 2025 Shazia Nazar, Syeda Hina Abbas, Syeda Sana Abbas

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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