COMPARISON OF DISEASE ACTIVITY IN ANTI-MUTATED CITRULLINATED VIMENTIN POSITIVE AND ANTI-MUTATED CITRULLINATED VIMENTIN NEGATIVE SUBJECTS WITH RHEUMATOID ARTHRITIS
Original Article

Keywords

Arthritis
Antibody
Blood
Laboratory

How to Cite

Shah, B., Mushtaq, S., Saeed, A., Khan, M., & Javed, A. (2021). COMPARISON OF DISEASE ACTIVITY IN ANTI-MUTATED CITRULLINATED VIMENTIN POSITIVE AND ANTI-MUTATED CITRULLINATED VIMENTIN NEGATIVE SUBJECTS WITH RHEUMATOID ARTHRITIS. Annals of Allied Health Sciences, 7(1), 17-20. Retrieved from http://aahs.kmu.edu.pk/index.php/aahs/article/view/95

Abstract

Objective: To compare disease activity in anti-mutated citrullinated vimentin (MCV) positive and anti-MCV negative subjects with rheumatoid arthritis.

Material & Methods: A cross-sectional study was carried out at University of Health Sciences Lahore. Fifty eight diagnosed rheumatoid arthritis subjects who fulfill the American College of Rheumatology criteria were recruited from Fatima Memorial Hospital. For laboratory investigation, venous blood sample was obtained from the participants. Serum  extraction was performed through centrifugation and placed at -20°C for further investigation. Anti-MCV antibodies was evaluated using ELISA. Disease Activity Scores (DAS-28) scoring was done in both groups (aMCV+ive and aMCV –ive Rheumatoid arthritis patients) and comparison was done.

Results: Considerable difference was noted in the DAS-28, tender joint count , swollen joint count  and erythrocyte sedimentation rate of Anti-MCV+ive and Anti-MCV-ive patients.

Conclusion: Anti-MCV+ive subjects disease activity scores were higher as compared to Anti-MCV-ive patients.

Original Article
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