COMPARISON OF DISEASE ACTIVITY IN ANTI-MUTATED CITRULLINATED VIMENTIN POSITIVE AND ANTI-MUTATED CITRULLINATED VIMENTIN NEGATIVE SUBJECTS WITH RHEUMATOID ARTHRITIS

Authors

  • Bushra Gohar Shah Department of Physiology, Sahara Medical College Narowal
  • Saira Mushtaq Department of Biochemistry, Abwa Medical College Faisalabad
  • Asma Saeed Department of Pharmacology, Multan Medical and Dental College Multan
  • Mohammad Faisal Khan Department of Biochemistry, Multan Medical and Dental College, Multan
  • Asad Javed Department of Physiology, Sahara Medical College Narowal

Keywords:

Arthritis, Antibody, Blood, Laboratory

Abstract

Objective: To compare disease activity in anti-mutated citrullinated vimentin (MCV) positive and anti-MCV negative subjects with rheumatoid arthritis.

Material & Methods: A cross-sectional study was carried out at University of Health Sciences Lahore. Fifty eight diagnosed rheumatoid arthritis subjects who fulfill the American College of Rheumatology criteria were recruited from Fatima Memorial Hospital. For laboratory investigation, venous blood sample was obtained from the participants. Serum  extraction was performed through centrifugation and placed at -20°C for further investigation. Anti-MCV antibodies was evaluated using ELISA. Disease Activity Scores (DAS-28) scoring was done in both groups (aMCV+ive and aMCV –ive Rheumatoid arthritis patients) and comparison was done.

Results: Considerable difference was noted in the DAS-28, tender joint count , swollen joint count  and erythrocyte sedimentation rate of Anti-MCV+ive and Anti-MCV-ive patients.

Conclusion: Anti-MCV+ive subjects disease activity scores were higher as compared to Anti-MCV-ive patients.

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Published

2021-06-30

How to Cite

Shah, B. G., Mushtaq, S., Saeed, A., Khan, M. F., & Javed, A. (2021). COMPARISON OF DISEASE ACTIVITY IN ANTI-MUTATED CITRULLINATED VIMENTIN POSITIVE AND ANTI-MUTATED CITRULLINATED VIMENTIN NEGATIVE SUBJECTS WITH RHEUMATOID ARTHRITIS. Annals of Allied Health Sciences, 7(1), 17–20. Retrieved from http://aahs.kmu.edu.pk/index.php/aahs/article/view/95

Issue

Vol. 7 No. 1 (2021): Annals of Allied Health Sciences

Section

Articles

License

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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