ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF NEONATAL SEPSIS IN NEONATAL INTENSIVE CARE UNIT

Authors

  • Hafsa Waseem Department of Pathology, Al-Nafees Medical College and Hospital Islamabad
  • Rabia Sadaf Department of Pathology, Rawal Medical College Islamabad
  • Abdul Jalil Khan Department of Public Health & Social Sciences, Khyber Medical University Peshawar
  • Afnan Naeem Department of Pathology, Army Medical College Rawalpindi
  • Sakhawat Ali Department of Pathology, Army Medical College Rawalpindi
  • Javaid Usman Department of Pathology, Army Medical College Rawalpindi

Keywords:

Antibiotics, Bacteria, Neonates, Sepsis

Abstract

Objective: To determine the antimicrobial susceptibility pattern of neonatal sepsis in the neonatal intensive care unit.

Material & Methods: A cross-sectional study was conducted from January to July 2018 at the department of microbiology, Army medical college Rawalpindi. Blood and MacConkey agar were used for colony identification and pigment production, Gram stain was done to identify Gram-positive and Gram-negative bacteria, Rapid tests like catalase, coagulase, motility, and oxidase were performed, and API 10S and 20 E were used to identify at genus and species level. For sensitivity testing of antimicrobials modified Kirby- Bauer Disk Diffusion method was used. Data was analyzed in SPSS.

Results: Out of the total of 470 samples 137(29%) were positive. Gram-positive were 43(31.3%) and Gram-negative were 94(68.6%). Maximum organisms were Stenotrophomonas maltophilia and Serratia marscenes which were 26 (19%) each followed by Klebsiella pneumoniae 18 (13.1%) and others. Pathogens showed 100% resistance to ampicillin and were maximum sensitive to colistin. However, Gram-positive were 100% sensitive to minocycline and linezolid and Gram-negative showed maximum sensitivity towards tigycycline which is 75.4%.

Conclusion: Minocycline or linezolid in combination with tigycycline is the drug of choice for the management of neonatal sepsis.

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Published

2022-06-30

How to Cite

Waseem, H., Sadaf, R., Khan, A. J., Naeem, A., Ali, S., & Usman, J. (2022). ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF NEONATAL SEPSIS IN NEONATAL INTENSIVE CARE UNIT. Annals of Allied Health Sciences, 8(1), 9–13. Retrieved from https://aahs.kmu.edu.pk/index.php/aahs/article/view/133

Issue

Vol. 8 No. 1 (2022): Annals of Allied Health Sciences

Section

Articles

License

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.