Aim: The purpose of this study was to evaluate sTfR and ferritin level in beta thalassemia major for diagnosis and management of iron chelating therapy.
Materials and methods: This study was conducted on 400 samples from β thalassemia major patients. ELISA technique was used for the detection of serum ferritin and sTfR according to the manufacturer’s instructions.
Results: In male beta thalassemia major patients sTfR level was 89.2±20.1 nmol/l while in female patients mean sTfR was 97.4±23.3 nmol/l which were high on comparing with control. Serum ferritin level in male patient was 3013.35±914.08 ng/ml while in female patients was 3213.43±1014.08 ng/ml.
Conclusion: The concentration of sTfR, and ferritin level was increased in beta thalassemia major patients which indicate increased marrow activity and increased body iron.